By focusing primarily on childhood health and education, Mrs Trump's five-day swing through four African states, her first significant solo trip overseas as First Lady, is meant to cast American diplomacy in a gentler light.
There to receive her was Ghana's First Lady, Rebecca Akufo-Addo.
Some of the mothers whose babies were cuddled by the American First Lady were too excited upon seeing their babies in the arms of Mrs Trump.
The US first lady stepped off an overnight flight from Andrews Airforce Base near Washington and onto a red carpet at Accra's Kotoka International Airport. The items carried the logo of "Be Best", the child well-being initiative Mrs. Trump launched last May.
Massive wave hits Palu in Indonesia
Indonesia's meteorological and geophysics agency BMKG issued a tsunami warning after the quake, but lifted it 34 minutes later. Hundreds of people were injured and hospitals, damaged by the quake, were overwhelmed. "There are 30 dead at our hospital".
Mothers at the hospital for her visit received gifts of teddy bears nestled in white baby blankets, personally handed out by the first lady, according to her spokesperson, Stephanie Grisham.
Her immediate predecessor Michelle Obama also made a solo trip to the continent when her husband was president, visiting South Africa and Botswana.
Next up, she was headed off to a private tea with the First Lady of Ghana at the presidential palace.
But as Melania Trump attempts to step out of her husband's shadow, this trip has been seen as an attempt for her to carve her own diplomatic path.
Mrs. Trump's visit opened in low-key fashion. Check it out below to hear what folks from Ghana, Egypt and Kenya had to say. Trump clapped her hands and waved at a group of school children waiting for her at the airport.