The Senate is expected to confirm Kavanaugh on Saturday.
Joe Manchin is facing a hard re-election campaign in West Virginia, a traditionally Republican state that Mr Trump won by a landslide. Steve Daines, whose daughter is getting married out of town Saturday. The final result was 50 to 48 in favor of Kavanaugh.
Collins added she will announce her ultimate decision on Kavanaugh's confirmation at 3 p.m. ET Friday.
"We have to think about what it would mean if Judge Kavanaugh were to be confirmed to the Supreme Court with credible sexual assault allegations against him", Durbin said from the Senate floor on Friday.
Even so, Democrats called for Kavanaugh to withdraw his nomination.
"You are a coward!" They raised concerns about his judicial philosophy and how he would rule on abortion and health care issues.
Flake's "yes" vote - combined with his comments Thursday that the FBI's supplemental investigation had been thorough and provided no corroborating evidence of the allegations made by Christine Blasey Ford and Deborah Ramirez - suggest he will nearly certainly be a "yes" on final confirmation.
While there were protests against Kavanaugh prior the Christine Blasey Ford stepping forward to accuse him of sexual assault, the demonstrations ramped up after the Senate Judiciary hearing with the accuser and accused.
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Kavanaugh gives the conservatives their first reliable majority on the nine-person panel since the mid-20th century, and though Democrats could attempt to impeach the judge in the future, they will need two-thirds backing in Senate, something that is considered unlikely unless new firm allegations come to light.
Yet none of that was enough to sway Republicans to oppose Kavanaugh.
"The four witnesses she named could not corroborate any of the events of that evening gathering where she says the assault occurred", she said. "A small but crucial group of lawmakers who'd been on the fence now coming out and saying they will support him putting Kavanaugh on a glidepath to the nation's highest court".
Meanwhile, Republicans raged against the other women's accusations.
With Collins voting yes, Kavanaugh's confirmation is all but certain. Lindsey Graham (S.C.) ― this was a straightforward "gang rape" accusation, one so obviously ridiculous that it became a rallying cry.
Supreme Court nominee Brett Kavanaugh secures the votes needed, including a "yes" vote from key swing Republican senators Susan Collins and Jeff Flake, as well as Democrat Joe Manchin, to be confirmed in a final vote on Saturday.
The senate voted 51-to-49 to advance Kavanaugh's nomination to a floor vote.
"It's been a great political gift for us".
Senate Republicans, not the White House, set the scope of the Federal Bureau of Investigation probe into sexual assault allegations against Brett Kavanaugh, including the decision not to interview the Supreme Court nominee or accuser Christine Blasey Ford, said Senate Majority Leader Mitch McConnell. To deny she knows her attacker is to deny her entire story.