Meng's disappearance is being investigated by French police, according to media citing police sources.
Meng Hongwei, the Chinese president of worldwide law enforcement agency Interpol who was reported missing to French police by his wife, is under investigation in China, a source told the South China Morning Post.
Interpol is the global policing agency, which helps officers in different jurisdictions pursue criminals worldwide.
His wife has not heard from him since.
An image from Interpol showing Meng Hongwei, Chinese President of Interpol, speaking in Bali, Nov. 10, 2016.
The global law enforcement agency based in Lyon, France did not provide details about Meng's disappearance and said in a statement Friday: "This is a matter for the relevant authorities in both France and China".
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But Interpol has in the past denied this, saying its head does not intervene in day-to-day operations, which are handled by secretary-general Juergen Stock, a German. He appears to have moved swiftly into the central government in Beijing, acting as an assistant to the public security minister - China's top cop - as well as head of the transportation department.
It was initially unclear where Meng had gone missing, but a source in the European country said: "He did not disappear in France". His term runs until 2020.
Interpol president has been reported missing after travelling to his native country China. "Exchanges with Chinese authorities continue", the ministry added.
He is the first Chinese national to hold the post.
Meng's wife alerted the French authorities, leading to the opening of the probe, Europe 1 radio reported earlier, without specifying how it had obtained the information.