Manning's record stood since 2015 when the future Hall of Famer passed Brett Favre's mark of 71,838 yards, which had been in place since 2007.
Brees previously set an National Football League record for most career completions in Week 3, surpassing Favre's mark of 6,300 as he connected with wide receiver Michael Thomas on a 17-yard pass against the Falcons.
The Redskins (2-2) scored 13 points in the first half on field goals of 37 and 53 yards by Dustin Hopkins and a 4-yard run by Alex Smith after Washington recovered a Cameron Meredith fumble late in the first half. The Los Angeles Rams (5-0) are the only NFC team with a better record than the Saints. "I just play because I love the game and I love to compete and I love being part of this organization".
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After the touchdown, Brees' Saints teammates jumped around to celebrate the big accomplishment with him.
Brees also connected with Smith on a 35-yard touchdown pass on the first series of the second half.
Peterson carried four times for six yards and caught two passes for 36 yards.
Tre'Quan Smith, three catches for 111 yards and two TDs.