Joe Manchin (D-W.Va.), who voted with the Republicans despite "reservations" about Kavanaugh's character and the accusations against him. The lifetime appointment means the 53-year old Kavanaugh's may serve on the highest court for decades.
"I've never considered a president's party or identity" in confirming a Supreme Court justice, Collins said, adding that she confirmed President Obama's Supreme Court picks Justice Elena Kagan and Justice Sonia Sotomayor.
Accusations against Kavanaugh energized the #MeToo social media movement that emerged after high-profile accusations of sexual assault and harassment by men in politics, the media and the entertainment industry.
Sen. Susan Collins (R-Maine) said she's going to vote in favor of Judge Brett Kavanaugh's nomination to the Supreme Court.
Hundreds of demonstrators protested on Capitol Hill, chanting "vote them out" and "November is coming".
Earlier Trump tweeted his support for Kavanaugh and praised crowds gathered at the Capitol to support the nominee.
If Kavanaugh joins a five-member bloc of Republican judges that makes it more hard for women to get an abortion, or interferes with the Environmental Protection Agency's ability to control air pollution that comes to ME from the Midwest, or protects President Trump from legal action, Collins will own a share of the blame.
Kavanaugh's two-vote victory in itself underscored how unusually divisive his nomination fight has been.
It was most obvious when it came to the law regarding a woman's right to choose to end a pregnancy, something Collins says she supports.
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And they said his record and fuming testimony at a now famous Senate Judiciary Committee hearing showed he lacked the fairness, temperament and even honesty to become a justice. She told reporters Friday that Kavanaugh is "a good man" but maybe "not the right man for the court at this time".
"This is one of the reasons I chose him is because there is no one with a squeaky clean past like Brett Kavanaugh".
Republican Sen. Lisa Murkowski, a moderate from Alaska, voted against advancing Kavanaugh in Friday morning's procedural vote.
Arizona Republican Jeff Flake, the other senator who had been wavering this week, said Friday he will vote to confirm Kavanaugh unless something significant changes.
The upper house is split 51-49 in favour of the Republicans and the vote was largely along party lines.
In the end, Republicans were able to use their monopoly on political power on Capitol Hill and the White House to muscle through the confirmation, which was almost derailed by Christine Blasey Ford's allegations that the judge assaulted her when they were teenagers in the 1980s.
But Murkowski ultimately withdrew herself from the final tally as a gesture of goodwill toward her Republican colleague, Sen.
The US President said before he headed to Kansas to watch the vote: 'We're really looking forward to the vote.
"Nothing unifies Republicans like a court fight", McConnell said in an interview ahead of the vote. Collins has not announced how she will vote. But as soon as Pence motioned to proceed with the vote, protesters began yelling It started with a few voices; one person could be heard yelling, "Where's my representation?"