A relatively quiet game burst into life in the 40th minute when Varane sprinted clear of his marker to meet a well-placed Griezmann free kick with a perfectly angled header.
If France win, Simeone will be unable to count on Lucas but if Uruguay go on to the semi-final, he will be without Godin and Gimenez.
"We all saw that it was not a very common goal, but Muslera has been a very important pillar for all this process and through all our work on our way up to here, so I'm not going to wash my hands putting any responsibility on my players", Uruguay coach Oscar Tabarez said.
Griezmann, though, knows Godin and another Atletico teammate, Jose Maria Gimenez, will not give Mbappe the same space to exploit his pace that a disorganised Argentina did.
France are into the World Cup semi-finals after a 2-0 victory over Uruguay in Nizhny Novgorod. His exceptional hat-trick against Bolivia ensured that Argentina would make it through to the finals of the World Cup but the side flattered to deceive during their stay in Russian Federation. "I'll support him as a friend and teammate so that he gets his head back up as soon as possible". "Apart from that, they didn't have many great opportunities".
Arsene Wenger's prediction about Jordan Pickford backfires after England beat Colombia
The vibrant Colombia fans belted out their national anthem and bounced in unison, swinging scarves above their heads. And, after experiencing his first World Cup, Falcao believes his team will only get better in the next few years.
The Atlético Madrid star has been involved in all four of France's games at the World Cup this summer, scoring in their first match against Australia and most recently in a thrilling win over Argentina, with both goals coming from the penalty spot.
Paul Pogba 8 - Ran the show for France as he continued to show that he can play in a midfield two, contrary to popular belief.
"About Mbappe, everybody knows he's a really good player, he's like (Thierry) Henry a few years ago", Uruguay's own hotshot Luis Suarez told reporters after training on Tuesday.
Portugal's Cristiano Ronaldo helps injured Uruguay's Edinson Cavani walking out during the round of 16 match between Uruguay and Portugal at the 2018 soccer World Cup at the Fisht Stadium in Sochi, Russia, Saturday, June 30, 2018.
"We have played without Edinson already, during qualification, and the team adapted to the situation", explained Suarez.