Uruguay, the team with the best defensive record in the group stage at the 2018 FIFA World Cup Russia™ with zero goals conceded, held firm to sink Portugal 2-1 in Sochi on Saturday to set up a quarter-final tie against France.
Raphael Gurrero whipped in a cross from a short corner and as the ball crossed Ronaldo's head, Pepe jumped high to meet the cross and fetch the equaliser for his side 10 minutes into the second half.
But his fitness will now be a major worry for Uruguay, who showed in this game that they have the credentials to go all the way in Russian Federation - if El Matador is healthy. Uruguay, meanwhile, had not conceded a goal in 2018 - an impressive run of six games, three of them at Russian Federation 2018.
Uruguay's hero of the evening, Cavani had to be substituted due to what looked like to be a muscle pull.
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Calls of "Raus" (Out) and " Auf Wiedersehen " (Goodbye) rang out from the fan zone as the weight of the 2-0 loss sunk in. Despite the loss, and because of South Korea's win over Germany, Mexico also advances as runners-up in the group.
Against Uruguay, though, we saw the reality of Portugal's overreliance on the Real Madrid forward. "There is a tournament in September, the Uefa League of Nations, and we hope that he is with us so that he can help the young players who will need their captain's example". It was a towering header from an unmarked Pepe - his sixth for his country. For Portugal, Andre Silva is in for Goncalo Guedes. His presence then meant Portugal's right-back Ricardo Pereira squeezed, allowing Cavani the space to score.
Portugal's triumphant Euro 2016 campaign was never spectacular but it made the most of what they had available - a world-class striker, a strong defence, a good goalkeeper, a winning mentality and good organisation.
Uruguay coach Oscar Tabarez lauded his side's dedication and commitment on Saturday, after a hard-fought 2-1 win over Portugal took them into the quarterfinals of the World Cup.
The 33-year-old has won nearly everything there is to win as a player - but he is now unlikely to ever lift the World Cup.
This could be the end of Cristiano Ronaldo, who at 33, must know he cannot get his hands on the biggest football prize anymore and he still failed to score in the second round of the FIFA World Cup.