It's not going to be easy at all, as has been the case for about a couple of decades against Arsene Wenger, but the hosts are up against a team with the worst away record in English League football since the turn of the year, which should inspire them to some extent.
Speaking after his side's 3-1 defeat on Wednesday - a result that stretches their run of consecutive Premier League losses on the road to seven - Wenger was less than impressed with two key decisions.
Star Sports Select 2 and Star Sports Select 2 HD will provide live television coverage of the match in India.
Petr Cech should start between the posts just like he did against Burnley on Sunday. The Foxes have lost four of their last five games, picking up only one point.
Mesut Ozil will miss the rest of the season with a back injury, but is expected to be fit for the World Cup in Russian Federation.
Laurent Koscielny considers his Achilles surgery to have been a success, with the Arsenal defender starting a six-month "fight" to recover full fitness.
Riyad Mahrez has had a memorable time at Leicester City, and he'll undoubtedly go down as one of the best players to have ever represented the club.
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Meanwhile, Puel believes Wenger is irreplaceable as he prepares to leave Arsenal.
Wenger has been been linked to the general manager's job at PSG, who are expected to replace their manager Unai Emery.
"It was very nice to hear applause from both sets of fans and I'm very grateful for that".
"Obviously, we know Wenger is leaving and they want to give him a good send-off by picking up wins in their last couple of games, so we want to try and spoil the party", he said.
Amongst the favourites to be appointed the new Arsenal manager are former Barcelona boss Luis Enrique, Juventus manager Max Allegri and New York City's head coach Patrick Vieira. It is always tough like after Sir Alex Ferguson, it was tough for the manager afterwardsPuel said, as quoted by ESPN.
Arsenal want to appoint their new manager before the start of the World Cup in Russian Federation in June, but face a race against time to meet that deadline.