Daniel Carvajal also followed Salah off in tears with an injury shortly afterwards but the Salah substitution was the real turning point in the opening half as Real Madrid really started to come into the game showing much more confidence and displaying much more efficiency in their passing.
Karim Benzema opened the scoring for Real Madrid after a horrendous clanger from Karius before Sadio Mane leveled things up not long after.
Liverpool had been the last side to beat Real Madrid in a Champions League or European Cup final, in 1981.
It remains to be seen if Zidane will select Bale for his starting XI in the Champions League final, with the Spanish giants set to take on the Reds in Kiev this weekend, though Nacho insists that Real would be pursuing the 28-year-old's signature if he was on the books at Anfield.
Two minutes later he gave Real Madrid the lead with a wonder goal and a finish fitting for any European final. He generally hasn't started in Champions League games because he's been struggling with his fitness.
Mane hit the post for Liverpool in between Bale's strikes, but they will have to wait a while yet before winning their sixth European Cup.
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Williams played as an unseeded competitor at the 2018 BNP Paribas Open and at the 2018 Miami Open. Likewise, it's a scary prospect for the top-ranked players who may have to face Williams early on.
A move back to the Premier League to Manchester United remains a possibility for a player who will be 29 in July, but for those who doubt Bale's ability to have an impact for Real, he showed in emphatic style that he remains a world-class player with his supersub display against Liverpool.
The goalkeeping position has been a source of concern for Liverpool supporters the entire season, with manager Jurgen Klopp finally settling on Karius after benching Simon Mignolet.
Zidane watched on with a smile on his face in the closing stages as his team turned on the style and in truth they could've won by five or six.
"I never really got to talk to Klopp", he added.
"They remind me of the Real Madrid of days gone by, with fast, pacey forwards".
Liverpool have netted 40 goals in Europe this season, with Salah bagging 10 of those, while Mane and Firmino have both scored nine.