Known for her roles in 80s B-grade movies and voluptuous figure, she's managed to make a name for herself and remain in the spotlight after going under the knife for numerous procedures.
She has been married to Italian producer Mattia Dessì since 2006 and was also previously married to Raoul Meyer, Sebastian Copeland, and Kasper Winding.
The Danish actress shared the news in an Instagram post, with the caption, "family getting larger #me #family #brigittenielsen #babybump". Aside from her social media messages, the actor has not publicly commented on the pregnancy.
"On Friday, the star posted an adorable throwback to Instagram - showing a rare insight into three of her sons" early years.
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Weisz announced in April that she was expecting a baby with husband Daniel Craig at the age of 48.
Nielsen, who was also a model before she went into acting, has been married five times.
Nielsen had a very public battle with the bottle after her 1987 divorce from Stallone - they were married just two years - and she was most recently in rehab in 2007.
Remember when she dated Flavor Flav??
It will be her fifth child after her four sons Julian, 34, Killian, 28, Douglas, 25, and Raoul, 23.