Atletico, the 2010 and 2012 Europa League winners, have now won their past nine matches at the Wanda Metropolitano.
Arsenal were unable to add to their tally in the second half but they will head to Russia's capital for the second leg next Thursday with a commanding lead.
The Spain global has since sat out LaLiga fixtures against Villarreal and Deportivo La Coruna but returned to training with the first-team squad earlier this week.
Leipzig edged past Marseille 1-0 while Lazio ended Salzburg's unbeaten run of 35 games with a 4-2 win in Rome.
Here is the Europa League quarters 1st-leg summary.
Midfielder Koke struck after just 22 seconds following an inviting ball from Diego Costa.
Aleksandr Golovin curled home a wonderful free-kick after haphazard defending from Shkodran Mustafi and Laurent Koscielny to level six minutes later.
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For comparison, the ISS is 357 feet (109 m) long and has an internal pressurized volume of 32,333 cubic feet (916 cubic m). As demand grows, Orion Span will launch additional modules to link up with the original core outpost, Bunger said.
Arsenal then restored its lead as Lacazette converted a penalty in the 23rd minute after Mesut Ozil was fouled.
The French global has 16 goals in his last 15 matches for Atletico in all competitions. If we had to play against Bayern Munich they would say it's an impossible game but if it was against Astana they would say it's easy, but the truth is you have to play every game and we always try to do our best to qualify for the next rounds.
Winning European football's second-tier competition would give Arsenal a route back into the Champions League.
"Indeed, we think we're even [with Sporting] for this qualifying round, Sporting have a great coach, a very capable man, the teams he's trained always did a good job".
But Felipe Anderson and Ciro Immobile, who has now scored 37 goals this season, put Lazio in control of the tie.
RB Leipzig in a match with "Marseilles" for the first time in its short history has kept his goal intact, and the only goal, Timo Werner brought the Germans to the semifinals.