It was also the city's biggest cricket match in nine years, after terrorist attacks resulted in the suspension of worldwide cricket in Pakistan.
PCB chairman Najam Sethi said more cricket will follow.
Spectators had to use a shuttle service before walking more than a kilometre and through two security checkpoints to get to the match, AP reports.
The attacks forced Pakistan cricket into exile, with worldwide teams refusing to tour the terror-hit country over security fears and the national team left to play its home matches in the United Arab Emirates (UAE).
The matches in Dubai have failed to attract sizable crowds in Dubai barring Thursdays and Fridays. This year, we are already staging a few games there.
Billboards and player cut-outs have been displayed on the sides of main streets to celebrate an international-standard game for the first time in almost a decade. "It will be real fun for players to play in front of their fans in Pakistan".
Pakistan's largest city hosted this decade's biggest match between Islamabad United and Peshawar Zalmi - the finalists of PSL - as global cricket returns to the country after a gap of nearly nine years.
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Akhtar, who claimed 444 wickets in all formats for Pakistan in a glittering 14-year career, said their participation was his "biggest concern" moving forward.
The 36-year-old scored a 27-ball 77 studded with eight well-timed sixes and five boundaries to lift his team to 170-7 in 16-over-a-side game following a rain delay at a packed Gaddafi Stadium.
When and where to watch the PSL Final between Peshawar Zalmi vs Islamabad United?
Peshawar Zalmi captain Darren Sammy was star of the night during the finals. "In my opinion, sports and politics should be kept apart". Faheem Ashraf walks out to bat, and hits the winning six off the fourth delivery that he faces, hooking it over the square-leg fence.
Chief Minister Murad Ali Shah and the Home Minister, Sohail Anwar Siyal will also be there to enjoy the match of the decade as the Sindh capital hosts an global event after nine good years. Pakistan Super League is a big event, he added. While the atmosphere was jubilant in Karachi's National Stadium, it was pretty much the same inside the Central Jail, where fans chants slogans supporting their respective teams.
"West Indies' three matches at Karachi next month truly heralds the return of global cricket to Pakistan", added Alam, the student.