Small study suggests ibuprofen alters testosterone metabolism

Adjust Comment Print

Researchers looked at 31 male participants and found that taking ibuprofen reduced production of testosterone by almost a quarter in the space of around six weeks.

However, for men, it could compromise their ability to procreate, a new study suggests.

"Prescribing providers rarely mention these adverse effects with patients when prescribing these medications", she said, according to CNN, noting that the study was "important" and that the use of ibuprofen could have a far greater negative effect on men who already have low fertility.

Despite the results, a lecturer says casual use of the non-steroidal anti-inflammatory drug (NSAID) by men should be just fine.

Researchers tested testicles from prostate cancer donors and cultured testes cells, which revealed that ibuprofen can affect hormones, suppressing production of testosterone through transcriptional repression, leading to compensated hypogonadism. And now, new research shows that it can cause infertility, erectile dysfunction, muscle atrophy and fatigue in men.

Though the exact reasons for the decline are not yet known; in a recent study, researchers have linked male infertility to Ibuprofen - a common painkiller. In common terms, the man's testicles don't secrete enough testosterone and the ability to produce sperm is impaired.

The research focused on men given 600mg of ibuprofen twice a day, which isn't the norm for the average bloke.

Florida man calls 911 to report himself drunk driving
The post also mentioned Lester's criminal history, which includes DUI, aggravated battery, drug possession and a hit-and-run. And since no one was hurt they used another hashtag "L-o-t-o" which the department says means "Laughing our tasers off".

The small study, which was published yesterday (Jan. 8) in the journal Proceedings of the National Academy of Sciences, found that men who took 1,200 milligrams of ibuprofen a day for six weeks developed a hormonal condition that is linked with reproductive problems.

Advil and Motrin are two brand names for ibuprofen. Hypogonadism is associated with impaired fertility, depression, heart failure, and stroke.

14 of them were given daily doses of Ibuprofen, which professional and amateur athletes take.

Typically seen in older men and smokers, the condition describes when the testes produce an insufficient amount of testosterone. The remaining 17 volunteers were given a placebo.

To avoid these side-effects, doctors caution against taking Ibuprofen for more longer than ten days in a row, per the FDA's warning.

"These are the first-ever results to show a link between ibuprofen and fertility", Bernard Jegou, a senior scientist at the French Medical Research Council and the school of public health at the Research Institute for Environmental and Occupational Health in France, who coordinated the study, told The Telegraph.