After Ron said, "We are honoured to be here to present the award for best director...", Natalie made her point in a short but effective way, by adding, "and here are the all-male nominees". "A new day is on the horizon", Oprah remarked.
Various people made a decision to wear black in solidarity with the victims who've come forth with allegations of sexual misconduct. It has also established a legal defense fund for victims of sexual assault.
"And here are the all male nominees", she said before reading out the list.
The statement won rave reviews on social media.
Immediately after Natalie's bold comment, stars like Jane The Virgin actress Gina Rodriguez, 33, and How To Get Away With Murder's Matt McGorry, tweeted their praise for Natalie.
But the person with the best line of the night was Natalie Portman.
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'Me and my friends just bawled out eyes out at Oprah's speech. "Then Natalie Portman was like HOLD MY BEER".
Meanwhile, Portman's searing one-line indictment quickly became the talk of Twitter.
Director Guillermo Del Toro went on to win the award for 'The Shape of Water, ' but many fans felt women directors like Greta Gerwig, Dee Rees and Patty Jenkins were unfairly shut out of the category.
That was for her 1984 movie "Yentl". That was 34 years ago. "Let's make our workplaces look more like our world", she said in a video before slipping into her black Dior Haute Couture Golden Globes dress. "The three highest-grossing films past year were all carried by women".
Winfrey spoke after she was awarded the prestigious Cecil B. DeMille award for lifetime achievement, the first black woman to be so honored.