Given the amount of times they have come up with late winners recently, you would have to say the omens are good.
Especially as only four of City's regular starters - Ederson, Fernandinho, Leroy Sane and Gabriel Jesus - played against Shakhtar, and that the last named has lost his place to Sergio Aguero in recent weeks anyway.
Gabriel Jesus also spoke on a next weekend's derby match against United, which he expects to be different: "It will be a good game, a great game, great players, great players".
Manchester City midfielder Yaya Toure has crowned his side the best in Europe on current form, citing their footballing style as second to none so far this season.
At the back, many are calling for Tosin Adarabioyo to start this one, which makes a lot of sense.
David Moyes's team threatened to end City's unbeaten record - which stands at 28 matches - when they took the lead through Angelo Ogbonna, but Nicolás Otamendi equalised before Silva secured a 13th straight win.
Bernard scored as Shakhtar Donetsk beat City 2-1 in the Champions League
Even then, things were not all bad. "I can promise you we are going to try to win the game". Brahim and Foden are City's two brightest youth prospects and any first-team opportunities can not be taken for granted.
"We are playing well but it does not mean we will go on to win the competition ..."
Kevin De Bruyne believes victory in next week's derby would see Manchester City strike a "massive blow" in the title race.
The 24-year-old France global said last week he hoped "very important" City players would suffer injuries in the title race. That is nine of 10 outfielders who have hardly been overworked of late.
Matic was forced off in the second-half of United's 4-2 win away at Watford on 28 November with what Mourinho later confirmed as a muscular problem, but played the full 90 minutes in Saturday's 3-1 victory over Arsenal at the Emirates Stadium.
A win for United meanwhile will see them become the first side to halt Guardiola's men this season.
NASA managed to launch off 37 years ago engines "Voyager-1"
The thrusters had not been in use for 37 years, since Voyager 1 made its trip past Saturn. The plan going forward is to switch to the TCM thrusters in January, it said.