The England forward thus toppled a 22-year-old record held by former England striker Alan Shearer.
Kane has played in 36 league matches this year, six fewer than Shearer's 1995 total.
Speaking of Messi, his 25th Clásico goal over the weekend in Barcelona's 0-3 win at the Santiago Bernabéu against Real Madrid saw him move onto 54 goals for club and country this year.
Three points from Tottenham's 5-2 win over Southampton in Boxing Day's early Premier League game. It also capped another late surge to personal glory after he scored seven goals in the final two games of last season to beat Romelu Lukaku to the Golden Boot.
It was Eriksen who provided the ball in from the left-hand side as it went towards the back post, it proved too easy for the England global as he rose highest to head home his 37th league goal of an astounding 2017.
And it's two more than Teddy Sheringham, who Kane (96) is now one behind in terms of most Premier League goals for Spurs.
India's First Air-Conditioned Suburban Train To Ply In Mumbai
Weekly, fortnightly and monthly season tickets would be charged the equivalent of 5, 7.5 and 10 single journeys of the AC local. On the inaugural run, the train began its journey from Borivli to Churchgate station of the Western Railway (WR).
Kane's second goal came with 20 minutes to go.
Eriksen, Dele Alli and Heung-Min Son combined to set up an easy finish for Kane in the 39th. When he topped last season's goal standings with 29 in 30 games, his scoring rate of 0.97 was the highest achieved by any Golden Boot victor in the league's 25-year history.
He would stunningly reduce the deficit to one after bagging his seveth hat-trick of 2017 away to a nominally formidable Burnley side at Turf Moor.
At full-back, Rose (who was so impressive for the all-important first goal) played as well as he has since returning from injury while Serge Aurier, who kept his place ahead of Kieran Trippier, was energetic and used the ball well.
"I think he deserves everything", Spurs boss Mauricio Pochettino said.
At both ends, they were missing key players but their lack of organisation and fight was embarrassing, proving far more costly than the absences of Virgil van Dijk and Charlie Austin.
In this kind of form, it would take a courageous man to bet against the Spurs forward clinching the Premier League Golden Boot come May. Sofiane Boufal pulled a goal back for Southampton in the 64th and substitute Dusan Tadic scored in the 82nd.