Spurs were left to lick their wounds after a fifth defeat of the campaign - one more than in the entirety of last season - which sent them slithering down the table to seventh. "We want to win each game, we're doing a good job", he said.
"I'm happy with the way we play - although I feel we can do much, much better".
So far the Colombia international's absence has been manageable, with the 5-1 hammering of Stoke City last weekend followed by the comfortable 2-0 victory over Brighton & Hove Albion in midweek proving somewhat straightforward.
"When I dropped points in those games, people said finally they have finished the run and I said you have to talk about what we've done", Guardiola said.
"We are such a humble team, as you can see in the performance today from Kevin De Bruyne".
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The Citizens extended their winning run to 16 games as they continue to exceed expectations and emphasise the gulf in quality between them and the rest of the Premier League.
A few minutes followed and more chances came the home side's way, with another effort from Gundogan bringing another save from the French goalkeeper and another great ball from de Bruyne nearly letting Leroy Sane in for a goal bar the German's heavy first touch.
In 12 games against his opposite number, Pochettino has only got the measure of Guardila twice; once at Espanyol, during their time in La Liga, and the other with Spurs.
They never appeared close to even replicating that against a team which had failed to beat them since May 2015.
Spurs sit in fourth place and a huge 18 points behind the league leaders, who have surpassed expectation by winning a huge 15 matches on the spin as the likes of David Silva, Kevin De Bruyne and Raheem Sterling rip up the form books.
The City bench erupted in fury shortly after when Alli caught De Bruyne high on the ankle in an very bad challenge and was shown only a yellow card.
"Typical City" - a term which plagued the blue half of Manchester in past decades - now has a very different meaning. He filed this report from Manchester's Etihad Stadium.