Adam Lallana will return to first-team training next week and could be fit for the Premier League fixture with former side Southampton on November 18, but Nathaniel Clyne has suffered a setback with his back injury.
They know, however, that defeat will further harm their chances of securing Champions League football for next season.
The Hammers' defence has been depleted over the last week with Jose Fonte and Sam Byram joining James Collins in the treatment room, while Pablo Zabaleta is suspended.
It looks as though the Reds will be without him again on Saturday as they aim to turn around their rotten form on the road this season.
Blizzard Announces New Overwatch Support Hero Moira at BlizzCon 2017
Her right hand fires a long-range beam weapon that saps enemies' health, healing Moira and replenishing her biotic energy. Earlier today, during the BlizzCon opening ceremony, Blizzard announced that a new hero is coming to Overwatch .
The German will be hoping for a similarly strong display this weekend, following 3-0 wins over Huddersfield Town and Maribor in the past seven days.
All of that's seems a moot point considering Jurgen Klopp's side will nearly certainly give up at least one goal, but the real question is whether or not they'll be able to grab a few of their own at the other end.
West Ham have endured a woeful start to their 2017/18 campaign, and now sit in 16th position in the Premier League table, after a return of just nine points from their opening 10 league outings. Mohamed Salah, who scored his 10th goal since moving from AS Roma during the summer on Wednesday, will keep familiar spot up top with Roberto Firmino. It feels a bit naughty to be moaning about transfers when the Hammers will be employing a makeshift defense, but that's how we feel every match, isn't it?