"France is fully aware of our country's firm position that Iran's defence affairs are not negotiable", said Qassemi ruling out possibility of any talks.
During his visit to the United Arab Emirates on Thursday, Macron suggested amending the JCPOA.
Tehran has dismissed calls to negotiate its ballistic activities voiced by French President Emmanuel Macron, who earlier considered amendments to the nuclear deal over Iran's missile program, and even sanctions "if necessary".
"What we have seen, clearly from the results of the ballistic missile attacks, that there have been Iranian markings on those missiles, that's been demonstrated", Harrigian said. Washington has also called for the United Nations to hold Tehran accountable for violating two United Nations security Council resolutions.
Referring to the Saudi claim, the French President had raised the prospect of possible sanctions with regard to those activities.
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During a visit to the Gulf, Macron blamed Iran for a ballistic missile launch by Yemeni rebels targeting Saudi Arabia last weekend.
Saudi Arabia and its allies accuse Iran of supplying missiles and other weapons to the Houthis, saying the arms were not present in Yemen before conflict broke out there in 2015.
"Responsible approach would oblige France to convince its regional allies to undertake more shrewd approaches and policies free from sentimentalism", articulated Mr. Qassemi. Paris, according to the spokesman, should remain "realistic, fair and farsighted" over "sensitive developments in the Middle East and the Persian Gulf regions".
"We expect France not to be swayed by inculcation and false signals sent by certain countries in the Persian Gulf region against the Islamic Republic of Iran", the Iranian spokesperson said.
The Yemeni army on November 5 confirmed that it had targeted Saudi Arabia's King Khalid International Airport in Riyadh with a long-range Borkan H2 ballistic missile.