An Unprecedented Study Has Revealed 72 New Breast Cancer Gene Variants

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"There were many women in the room at the launch who have had a breast cancer diagnosis. some of whom I have met and we have shared our experiences with each other".

About 70 per cent of breast cancer responds to the oestrogen hormone, which helps the tumour to grow.

The researchers believe that in future they could test for the genetic variants to prevent or treat the disease in women who are at higher risk.

The city is now looking at where to donate this year's proceeds, Bradshaw said, and is considering the Sisters Network, among different local breast cancer support organizations.

"We know that breast cancer is caused by complex interactions between these genetic variants and our environment, but these newly discovered markers bring the number of known variants associated with breast cancer to around 180". A team at the Cleveland Clinic found differences in the types and amounts of bacteria between cancerous and non-cancerous breast tissue.

While studying 21,468 ER-negative cases, the researchers identified 10 new gene mutations that could explain approximately 1.5 of the heritable risk of ER-negative breast cancer. That works out to 250,000 American women this year.

United States co-author Professor Peter Kraft, from the Harvard TH Chan School of Public Health, said the findings revealed a wealth of new information about the genetic mechanisms underlying the disease.

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"Information on these variants could be combined with other strong breast cancer risk factors, such as age, family history and mammographic density to provide more precise estimates of risk", said Associate Professor Roger Milne, epidemiology director of Cancer Council Victoria.

About one in eight women in countries such as the USA are expected to develop invasive breast cancer in their lifetime.

As healthcare providers, one of our responsibilities is counselling regarding lifestyle modification and adopting a healthy lifestyle and spreading awareness, both among the general population and breast cancer survivors.

Early detection and aggressive treatments have seen a decline in deaths from the disease, with survival rates now at around 90 percent after five years.

Professor John Bridgewater, an oncologist at University College London Hospital, who was not involved in the study, said: 'Many patients will often go on special diets, rather than having conventional treatment.

The study was conducted primarily among women of European background. "A better understanding of the biological basis of oestrogen receptor negative breast cancer may lead to more effective preventive interventions and treatments".

Professor Chenevix-Trench said a greater understanding of a particular woman's risk of developing breast cancer could help to change the age at which she was offered mammogram screening.

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