Midfield duo Paul Pogba and Nemanja Matic return to the Champions league after over a year out of it, and look nailed on to start, with Marouane Fellaini potentially joining them in the middle of the park after missing the trip to Stoke on Saturday.
Victor Lindelof and Chris Smalling had been twiddling their thumbs while centre-backs Eric Bailly and Phil Jones made a confident start to the season, but the chinks in that particular armour were ruthlessly exposed by...
Lindelof, who will partner Chris Smalling, endured a hard pre-season and has only made one competitive appearance for United, when he struggled in the Super Cup defeat to Real Madrid.
"We are a big club and maybe the biggest in the world but we were not in the Champions League last season and we have to take it step by step. I believe that he can score and I hope that he will score goals in the Champions League for us as well".
The Portuguese manager cited examples of defending champions Real Madrid and Juventus, who could rest players for their league games when competing in the later stages of Europe, which would be impossible for any team in England without sacrificing their league aspirations.
"I am not going to revolutionise what I want to do with this team due to one bad game", Zidane insisted afterwards.
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"I knew, last season, when I signed and came back here, that I would be playing in the Europa League".
Only Liverpool (5) have won more European Cup/Champions League titles than Manchester Utd (3) among English clubs.
Two of United's last three Champions League campaigns have been concluded in the group stages and Mourinho said: "There are many teams in the Champions League with similar qualities to the Europa League. I trust them. I am not anxious at all that Bailly and Jones are out".
Cristiano Ronaldo is eager to return to action as he prepares for his first start of the season when Real Madrid begin their Champions League defence on Wednesday against APOEL Nicosia, coach Zinedine Zidane said on Tuesday. They've netting 12 goals in four Premier League encounters, scoring six times in two Old Trafford outings.
"We have to try to qualify, we have to try to go to the last-16 and enjoy that special knockout phase with the best teams in Europe".
'For some players it is to go back, for some players it is the motivation of playing Champions League for the first time.