The Spaniard beat 2015 Roland Garros champion Wawrinka 6-2 6-3 6-1 to eclipse Pete Sampras on the all-time list of major champions with 15 titles - second only to Roger Federer's 18 titles.
After the heartbreak of losing the Australian Open final to Roger Federer earlier in the year, emotion overcame Nadal after the match, but he was ruthless for its entirety.
Only Bjorn Borg, who conceded 32 on his way to the 1978 title, has been a more ruthless champion.
First game of the third set and Nadal broke again as the man who stunned him in the 2014 Australian Open final suffered further damage.
He said: "It has been a while since I played a very good Wimbledon". The nerves and adrenaline I feel on this court is impossible to compare. "It's the most important tournament in my career and to win again is something I can't describe".
No Fed dread for bond markets with yields near multi-week lows
Near-term risks to the economic outlook appear roughly balanced, but the Committee is monitoring inflation developments closely. The initial cap will be set at $10 billion a month: $6 billion from Treasuries and $4 billion from mortgage-backed securities.
Rafael Nadal celebrates with the trophy and his Uncle Toni. Nadal continued to hold serve easily and then, getting his groundstrokes right and playing with plenty of depth, broke on Wawrinka's very next service game to take the lead 4-2.
"It's always been an honor to play against you", Wawrinka told Nadal as he addressed the crowd. He had beaten Nadal in a Grand Slam final before, after all - and the Swiss had just produced his best tennis Friday to beat world No. 1 Andy Murray in the semifinals.
King Of Clay is no longer a suitable title for Rafael Nadal when it comes to the French Open.
Nadal lost just 35 games at the tournament, the second-fewest that any player has dropped in any Grand Slam in history.
Nadal's 10th Roland Garros title is his 53rd on clay, the most won by a player on the surface in the Open Era. Nadal said when he first won the title in 2005 he would not have imagined he would still be playing in 2017, let alone winning, and said 10 titles had a special ring to it. They let out a burst of claps and roars in the second set on one particularly exquisite display: Wawrinka smacked a cross-court backhand to a corner, and Nadal sprinted to his left to get to the ball, wide of the doubles alley, and whip a forehand that curved around the net post and landed near a line for a victor. "If I did it, probably somebody else gonna do it, because I don't consider myself very special", he said. But not only here: since the beginning of the year, you can see he's playing more aggressively, staying closer to the line. That's clearly his best he ever played.
"It was the Rafa I was expecting".